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oli jones.
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January 29, 2025 at 1:20 am #34505
A 50% match, also known as a haploidentical match, means the donor shares half of their Human Leukocyte Antigen (HLA) genes with the recipient. This is a significant consideration for bone marrow transplants, as HLA proteins play a crucial role in the immune system.
HLA genes are a complex set of genes that determine a person’s tissue type. A perfect match occurs when all HLA genes are identical between donor and recipient. A haploidentical match means only half of these genes are identical.
This is a major concern with haploidentical transplants. GVHD occurs when the donor’s immune cells (transplanted with the bone marrow) attack the recipient’s tissues. The risk of GVHD is higher with a haploidentical match due to the mismatch in HLA genes. To minimize the risk of GVHD, specialized treatment approaches are used in bone marrow transplants.
Powerful medications are given to suppress the donor’s immune system and prevent it from attacking the recipient. Donor cells may undergo a process to remove T-cells, a type of immune cell that plays a key role in GVHD. Close monitoring and aggressive treatment are essential to manage potential complications like GVHD and infections.
Success rates for haploidentical BMT transplants have improved significantly in recent years due to advancements in treatment and supportive care. However, they are generally lower than those for fully matched transplants.
Haploidentical donors are often family members (parents, siblings, children), making them more readily available than fully matched unrelated donors. In situations where a rapid transplant is necessary, a haploidentical donor may be the best option.
The decision to proceed with a haploidentical bone marrow transplant is complex and should be made in consultation with a team of experienced medical professionals. They can assess the individual risks and benefits, discuss treatment options, and help guide the patient and their family through the decision-making process.
Visit our official to know more:- https://www.edhacare.com/treatments/organ-transplant/bone-marrow
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